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Seek medical review if you experience severe cold intolerance affecting daily life, cold sensitivity with dizziness or palpitations, rapid weight loss exceeding 0.5-1 kg weekly, or symptoms suggesting thyroid problems such as extreme fatigue, persistent constipation, or hair loss

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, Torregiani, E

In infectious disease treatment, the EPR effect may likewise result in NP accumulation at the infection area due to improved vascular permeability and reduced lymphatic function in inflamed tissues [200]

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J Biol Chem 1992;267:7402-5