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So, back to the question

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In conclusion, our data suggest that GSSG is a potent and clinically relevant sensitizer for TNF-induced hepatotoxicity in NAFLD, which represents a potential therapeutic target for NAFLD

(You may also see the term metabolic dysfunction-associated steatotic liver disease, or MASLD, used in newer literature, though NICE guidance currently refers to NAFLD.) Additionally, NAC possesses direct antioxidant properties and may help modulate inflammatory pathways within the liver

ALA may be helpful for: People with diabetic neuropathy: ALA has the strongest clinical evidence for reducing nerve pain and improving quality of life in this group.1 Those with type 2 diabetes or metabolic syndrome: Modest improvements in insulin sensitivity and blood sugar markers have been observed in some studies.24 People with high oxidative stress: Research shows that ALA can help lower oxidative stress markers like CRP in individuals with chronic inflammation or metabolic risk factors.27 Those with nerve-related conditions or mitochondrial dysfunction: Early research suggests ALA may help support nerve health in contexts like multiple sclerosis.3 However, ALA may not be appropriate if: Youre generally healthy and eat a balanced diet Your body naturally produces some ALA, and small amounts are found in foods like spinach, broccoli, red meat, and organ meats.41 In healthy individuals, taking an ALA supplement may offer little to no added benefit

While NAC differs from NAD+, it supports cellular energy indirectly by boosting glutathione production