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There is a theoretical risk of medullary thyroid carcinoma based on rodent studies, leading to a boxed warning and contraindication in patients with personal or family history of medullary thyroid cancer or Multiple Endocrine Neoplasia syndrome type 2

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doi: 10.1016/j.brainres.2015.06.041

And next year, Retatrutide is expected to enter the market, and this will work on 3 receptor sites, GLP-1, GIP and glucagon

Orthopaedic surgery is uniquely sensitive to small shifts in perioperative risk, particularly in implant-based procedures where complications carry disproportionate consequences