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An observational study comparing healthy adults found circulating levels of TMAO negatively correlated with MedDiet score after adjusting for BMI, physical activity, and total energy intake (123)
This means that, overall, tirzepatide is a more effective medication, but can cause more severe side effects, possibly to it being more potent due to its dual-action mechanism
Immunosenescence and Inflammaging: risk factors of severe COVID-19 in older people