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In patients with T2DM, insulin concentrations are often already supranormal, and treatment with exogenous insulin does not appear to increase protein synthesis, reduce muscle protein breakdown or improve mitochondrial function [170,171,172]

One study found that for every pound lost, four pounds of pressure are taken off the knees

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Animal models of most forms are not available for study, but the genetic manipulability of the mouse has begun to rectify this situation

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