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Metabolic phenotyping and indirect calorimetry Single-housed male DIO C57BL/6J mice were acclimatized to metabolic cages (16-channel Promethion, Sable Systems International) for 1 week before the start of the study

Several drugs were withdrawn from the market because they were ultimately not safe

In clinical trials, nausea, vomiting, diarrhoea, and constipation were among the most common complaints, particularly during dose escalation phases

Also, atmospheric oxygen can cause protein oxidation over time

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Synthesis of the antioxidant glutathione in neurons: supply by astrocytes of CysGly as precursor for neuronal glutathione