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Methods Islets were isolated from wild-type (WT), Gipr -knockout ( Gipr / ), Gcgr -knockout ( Gcgr / ), Glp-1r (also known as Glp1r )/ Gipr double-knockout and Trpm5 -knockout ( Trpm5 / ) mice, followed by assessment of beta cell function and insulin secretion in response to mono- and multi-agonist administration

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Concomitantly, clinical and experimental observations 70,71 have revealed that endogenous estrogens can protect against IR primarily through ER- activation in multiple tissues, including in the brain, liver, skeletal muscle, and adipose tissue, in addition to pancreatic cells

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Vitamin K This vitamin is essential to help heal injuries through blood clotting and strengthen bones

Through the fusion of TMPT1 with proteins or peptides with therapeutic efficacy, it can exert robust in vitro and in vivo antitumor activity