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In real-world clinical practice, endocrinologists frequently prescribe semaglutide to patients already on metformin, particularly those with type 2 diabetes seeking greater weight reduction or glycemic improvement

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its plasma half-life is approximately 10 to 20 minutes [1]

doi: 10.1038/ncomms14524

They also revealed that it has a strong detoxification effect and protects our body from the negative effects of heavy metals, drugs, radiation, cigarette smoke, alcohol and polluting factors

Hyperglycemia itself damages blood vessels through several mechanisms