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The percentage of apoptotic fibroblasts in keloids and normal skins increased from 3.31% 0.46% to 18.6% 9.44% and from 5.51% 3.34% to 25.42% 5.82%, respectively ( p = 0.04 and p = 0.01, respectively

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For instance, nanoparticles can be engineered to deliver antifibrotic drugs directly to activated HSCs, thereby reducing ECM production and fibrosis progression [15]

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TABLE 1 Hippo pathway influences intestinal diseases by affecting metabolism and the associated mechanism

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