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It is applied directly to the skin over the affected area

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doi: 10.1007/s11064-016-1995-9 412 MamashliFMeratanAAGhasemiAObeidiNSalmaniBAtarodDet al

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This model is created with influenza, viral infection molecules (poly(I:C)), bacterial mimics ( lipopolysaccharide ) and specific cytokines (such as IL-2 and IL-6)