At therapeutic doses it is safe for most people, but acetaminophen metabolism uses glutathione directly, and chronic high dose use is the leading cause of acute liver failure in the United States precisely because it exhausts hepatic glutathione (PubMed PMID: 26041729)
10.1161/HYP.0000000000000208 46 GilbertE
The observed reduction in inflammatory cell infiltration, lower vacuolar degeneration, and higher mitotic figures in hepatocytes with NP treatments, particularly in combination, corroborate the biochemical findings
Dutta D, Nagendra L, Harish BG, et al
Control acute inflammation early
It is usually safe to be used during the advanced stages of Adrenal Fatigue, although usually under the supervision of your healthcare provider