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For trials that fulfilled all inclusion criteria but did not mention pancreatic cancer events, an e-mail was sent to the corresponding author asking for the data

Your body naturally produces GLP-1 (glucagon-like peptide-1) in your intestinal L-cells in response to food intake

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In the SUSTAIN-6 trial, semaglutide was associated with a significant increased risk of diabetic retinopathy complications, including vitreous hemorrhage, blindness, or conditions requiring treatment with an intravitreal agent or photocoagulation (HR 1.76, 95% CI 1.112.78) [27]

Evidence based on recent studies Initially, cases of intestinal obstruction associated with GLP-1 RAs were reported by the European Medicines Agency (EMA) in 2013 [9], and this safety signal is currently being monitored by the United States (US) FDA