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3-adrenergic agonists enhance thermogenesis by activating Uncoupling Protein 1 (UCP1) in brown adipose tissue, which stimulates PKA-mediated lipolysis and increases energy expenditure [42]

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British Journal of Anaesthesia

S.DakhilS.HortobagyiG

Naltrexone and bupropion have independent actions in the brains reward system and in proopiomelanocortin (POMC) neurons of the hypothalamus, but it seems that the systemic effects of this combination produce a synergistic effect of decreasing food intake and weight

S.FogartyK