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Furthermore, MC4R agonism has also been implicated in learning and memory through LTP enhancement via cAMP-PKA cascades within the hippocampus [58]
Research Diets, D12108 C, 1.25% cholesterol) or an ALC-supplemented diet (300 mg/kg, Changzhou Shuiyushuer Company, Changzhou, China) for 4 weeks ( n = 6 mice per group)
Studies in rodents using doses of sitagliptin sufficient to inhibit intestinal but not systemic DPP4 activity implicate local intestinal-neural GLP-1R-dependent mechanisms for potentiation of glucoregulatory actions of DPP4 inhibitors (166)
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