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As a glucagon-like peptide-1 (GLP-1) receptor agonist, semaglutide mimics an intestinal hormone that stimulates insulin release, thereby lowering blood sugar

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These medications have known risks and boxed warnings , and some clinicians are appropriately cautious

It is not approved as a weight-loss medication, but some clinical trials have shown that it can support weight loss as a secondary benefit

Rats with fasting blood glucose concentrations 11.1 mmol/L for three continuous days were considered as successful diabetes models (Srinivasan et al., 2005)

Operational and Technical Challenges: Recruitment: Enrollment of a specific patient population, particularly one that is heterogeneous (obese individuals and T2DM patients), may pose recruitment challenges