Oxytocin controversially inhibits ACTH release in man (86-88) by competing for AVP receptor binding (89), but its more dominant effect seems to be a potentiation of the effects of CRH on ACTH release (90,91)
that's a legitimate conversation to have
This rapid onset of action makes it an excellent, fast-acting option for addressing acute moments of stress, sudden cognitive fatigue, or autonomic adrenaline dumps
Psychiatric applications include adjunct treatment for schizophrenia, where glycine may help manage symptoms when combined with antipsychotic medications
Melatonin receptors activate heteromeric G-protein coupled Kir3 channels
Combined therapy can produce insomnia, anxiety, tremor, and elevated heart rate (from phentermine) plus nausea, constipation, and vomiting (from semaglutide)