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Beyond obesity and weight-loss maintenance, ROSE-010 has also shown clinically meaningful, statistically significant pain relief in a separate Phase 2a study of patients with irritable bowel syndrome (IBS), supporting its potential as the first targeted, on-demand therapy for acute IBS pain

If results remain unexplained, particularly with very high levels, further investigation may include imaging or haematology referral depending on clinical context and associated abnormalities

Symptomatic vitamin deficiency is more likely if the person is rendered achlorhydric (a complete absence of gastric acid secretion), which occurs more frequently with proton pump inhibitors than H 2 blockers

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B12 is not a cure for clinical depression or anxiety, so persistent mood symptoms should be evaluated by a provider