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Elosegui, S., Lpez-Seoane, J., Martnez-Ferrn, M., Pareja-Galeano, H
RTD is among the most riboflavin-responsive genetic neurological disorders, with early diagnosis and high-dose supplementation (1050 mg/kg/day) capable of reversing neurological deficits ( Downstream, RFK (riboflavin kinase) is essential for converting riboflavin to FMN
MOTS-C is a mitochondrial-derived peptide
The hyperthyroidism in toxic multinodular goiter is milder than Graves disease and is gradual in onset, but acute presentations can occur when iodine replacement is given to an iodine-deficient individual
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This crosstalk amplifies neuroinflammatory signaling and alters neurovascular integrity, contributing to blood-brain barrier disruption, glial priming, and neuronal injury 11-12
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