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The biological activity of glutathione depends largely on the thiol (-SH) group of cysteine, which is vital for its antioxidant function and cellular redox homeostasis

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A varicocele can lead to excessive temperatures in the scrotum, which can consequently hinder the development of functional sperm, testicular histology, and productivity of reproductive hormones and increase the production of ROS [33,35,36]

Moreover, NO seems to be the only mediator of cell proliferation arrest through the ERK1/2-p53 signaling pathway (Aquilano et al., 2011a)