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In rodents and in humans genetic evidence demonstrates that the loss of SIM1 causes hyperphagic obesity in addition to causing resistance to the anorectic effects of melanocortins [68,69]

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doi: 10.1096/fj.00-0584fje

and acknowledgement that patient equity considerations must be balanced against theoretical safety concerns [48]

Studies have shown that adequate glutathione levels are essential for maintaining a robust immune system and defending against infections and diseases