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Conversely, SIM1 overexpression reduces food ingestion and body weight in mice fed a high-fat diet, acting downstream of melanocortin receptors [70]

In one embodiment, administration of any formulation described herein at about body temperature reduces or inhibits vertigo associated with intratympanic administration of otic formulations

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The peptide appears to promote mucosal healing through enhancement of epithelial cell proliferation and migration, restoration of tight junction integrity, and modulation of inflammatory responses within the gastrointestinal tract

The vitamin D binding protein polymorphisms are particularly relevant clinically because they affect both the transport and bioavailability of vitamin D metabolites