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The peptide decreased median healing time of skin ulcers by 45% compared to placebo when applied topically as a 0.03% cream for three months [20]

Its action is specific to adipocytes (fat cells) via beta-3 adrenergic receptors and does not affect anabolic pathways, protein synthesis signaling, or IGF-1 levels

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Interestingly, specifically in placentas from women with inflammation-driven PE, we observed the increased activity of NAD + -consuming enzymes, decreased NAD + content, decreased expression of mitochondrial proteins, and increased oxidative damage