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Effect of Subcutaneous Semaglutide vs Placebo as an Adjunct to Intensive Behavioral Therapy and Low-Calorie Diet in Adults With Overweight or Obesity: The STEP 3 Randomized Clinical Trial

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3.2.3 Neuroinflammatory imaging in Parkinsons disease Rats overexpressing mutant -synuclein exhibit early, region-specific ([18F]DPA714) binding increases in the substantia nigra and striatum prior to overt dopaminergic neuron loss and motor deficits, indicating that PET-detected microglial activation anticipates classical PD pathology (146)

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