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The Switching Protocol If switching from semaglutide to tirzepatide: Take your last dose of semaglutide as scheduled Wait one week (your normal injection day) Start tirzepatide at the initial dose recommended by your provider Follow the prescribed titration schedule Start tirzepatide at the dose recommended by your provider, even if you were on a higher dose of semaglutide

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This effect likely relates to the peptide's GABAergic and anti-NMDA activities

Furthermore, research on circadian biology suggests NAD+ is tied to the body clock, so morning supplementation might be optimal for metabolic syncing