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Long-term studies in mice show that Epithalon administration significantly extended maximum lifespan by 12.3% and increased the lifespan of the last 10% of survivors by 13.3% compared to control groups, while showing no adverse effects on body weight or food consumption

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10.1038/s43587-021-00080-0 198 SebastianiP.BaeH.GurinovichA.SoerensenM.PucaA.PerlsT

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Baseline photographs and examination every 6 to 12 months is recommended to detect evidence of growth

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Once a vial is reconstituted with bacteriostatic water, it should be stored in the refrigerator to help maintain stability

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Outpatient joint replacement is not done everywhere, however, and it is important to discuss this option with your individual surgeon

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The clinician should determine the appropriate treatment rather than the patient selecting solely by price

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