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The effect requires time (typically months 2 to 3 before visible changes) and is significantly enhanced by resistance training and appropriate dietary structure

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Mast cell activation syndrome (also referred to as mast cell activation disorder (MCAD)) is sometimes confused with histamine intolerance

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An AD in vitro study demonstrated heme-mediated increase of the basal expression of NRF2 antioxidant target genes (Zhang et al., 2021) (Table 3)