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10.1038/sj.npp.1301119 Neuropsychopharmacology

Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice

The protective effect was seen across a wide variety of addictive and habit-forming substances, including cocaine, opioids, alcohol, nicotine and cannabis, adding further evidence to a phenomenon previously flagged in smaller studies

This effect appears, however, to be limited by concomitant reductions in the inherent efficacy of ligand-bound receptors such that the peak efficacy does not continue to increase throughout the full range of internalization

BMJ Open 8 , e022599 (2018)

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