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For example, might people with borderline deficiency show modest metabolic responses that current trials missed

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For this example, we'll stick with 2 mL

Brain 145:e77e78 Loens S, Chorbadzhieva E, Kleimann A, Dressler D, Schrader C (2017) Effects of levodopa/carbidopa intestinal gel versus oral levodopa/carbidopa on B vitamin levels and neuropathy