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Berberine, a plant alkaloid with an extensive research history, has been studied for its ability to activate AMPK adenosine monophosphate-activated protein kinase, sometimes called the body's cellular fuel gauge

Free radicals are produced by normal body processes, like breathing and digestion, but they are also increased by external factors like pollution and UV rays

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The immunomodulatory metabolite itaconate derived from the TCA cycle was significantly boosted as a result of decreased isocitrate dehydrogenase 2 and increased immune-responsive gene 1 and mitochondrial citrate carrier in dapagliflozin-treated mice, accounting for the inhibitory effect of dapagliflozin on NLRP3 inflammasome activation (155)

Musar A, McCullagh K, Paul A, et al