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Published clinical trial data describe weekly dose-escalation protocols ranging from sub-milligram to low-milligram levels in controlled study populations

Recombinant basic fibroblast growth factor stimulates wound healing in healing-impaired db/db mice

S2CID 37997967

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Inconsistent dosing, including skipped doses, schedule changes without medical guidance, or stopping treatment too early

This increase in extracellular viscosity can be attributed to the accumulation of ECM degradation products [205]or macromolecules (e.g., Mucins [206]) caused by the collapse of the lymphatic drainage system [17, 18]