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The active factor was isolated and identified as this small peptide with a strong affinity for copper(II) ions

doi: 10.1016/j.jtemb.2023.127235 49 HussainSKhanMSheikhTMMMumtazMZChohanTAShamimSet al

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The washout allows tirzepatide levels (half-life 5 days) to drop substantially before adding a new triple agonist