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The ongoing FOCUS trial investigates the long-term effects of semaglutide compared with placebo on diabetic retinopathy, including relatively well-regulated (HbA1c 710%) patients with T2D (51)

The bioavailability of small molecule GLP-1 receptor agonists in humans remains to be elucidated

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It uses liraglutide, a slightly different GLP-1 medication than semaglutide, and requires daily injections rather than weekly

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According to researchers from the University of Pennsylvania and Cedars-Sinai Medical Center, the number of non-diabetic patients starting these medications jumped from 21,000 in 2019 to over 174,000 in 2023