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Specific Dosage Guidelines Severe Deficiency : For patients with severe vitamin B12 deficiency, an initial dose of 1 mg (1000 g) of intramuscular hydroxocobalamin is commonly administered

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Strong inhibition of the polyol pathway diverts glucose flux to protein glycation leading to rapid establishment of secondary complications in diabetes mellitus

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This further promotes an autoamplification loop that exaggerates inflammation and cell death and leads to a more severe degree of cell death and a range of inflammation-related responses [95, 96]