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2D we interestingly found that methylation profiling significantly impacted receptor tyrosine kinase and phospho-metabolism signaling pathways with also a concomitant action on T-cell activationrelated pathways and PD-1 signaling, highlighting the impact that DNA methylation deregulation could have on cell communication and other vital cellular processes like growth, differentiation and metabolism, but also on immune responses, as already hypothesized for the genesis an progression of this disease

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