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2012 Dec;32(6):797-803

The 1858 C/T SNP of the PTPN22 gene is a risk factor for HT because it causes an arginine-tryptophan substitution at codon 620 (R620W), because decreased T cell signaling may results in poorer thymic elimination of autoreactive T cells, or an increased function of PTPN22 may lead to a decrease in regulatory T cells (Tregs) responsible for preventing autoimmunity

How to Give Yourself Intramuscular (IM) Injections | Patients & Families | UW Health

Side Effects & Mitigation Reported effects come from the individual components research and practitioner reports

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