No randomised controlled trials have been published demonstrating efficacy in reducing disease activity, joint inflammation, or radiographic progression in patients with rheumatoid arthritis
The researchers found that turning off GLP-1 in the brain didnt affect the normal daily intake of food, but instead was important in several specific situations: prolonged fasting, large feedings, and stress-induced appetite loss.[ref] Controlling binging, regulating satiety: Essentially, the neurons activated by GLP-1 help to limit binging after a fast they keep you from massively overeating after not eating for a while
Moustafa PE, Abdelkader NF, El Awdan SA, El-Shabrawy OA, Zaki HF (2018) Liraglutide ameliorated peripheral neuropathy in diabetic rats: involvement of oxidative stress, inflammation and extracellular matrix remodeling
The MCAS paper suggested that MCAS-targeting rescue therapy (e.g., extra doses of H1/H2 receptor blockers) can help
The timing, associated symptoms, and clinical context are important in determining the cause
Functional imaging studies have shown that the hypothalamus activates before a migraine attack begins, sometimes hours before the pain starts
