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Furthermore, for specific compounds, additional key mechanisms such as Fas-mediated signal transduction, loss of cellular redox homeostasis, ATP depletion, changes in ion channels, and activation of kinases and caspases, among others, have been highlighted

Fourth, publication bias, language and time restrictions, and inadequate control of confounders such as diet, physical activity, BMI, comorbidities, and medications in most studies reduce the certainty of inferences