These dates were set outside the study period to ensure that follow-up wasnt initiated inappropriately late or terminated early simply due to natural intervals between redemptions (e.g., an individual with a prescription redemption in Jan 2019 mistakenly has follow-up terminated in early December 2018)
In 2018, the recommendations of the international evidence-based guidelines for the assessment and management of PCOS [1] indicated that, although its use is generally off label, metformin can be considered in addition to lifestyle in women with PCOS and Body Mass Index (BMI) 25 kg/m 2 to potentiate weight loss and to improve endocrine and metabolic outcomes
Buse JB, Rosenstock J, Sesti G et al
It could also reduce markers of liver inflammatory activities and support reduction in body weight, fat mass, and hip circumference, all while being safe and well-tolerated
Results from clinical trials suggest that such drugs could have potential for the treatment of asthma, which is one of the most chronic inflammatory pulmonary diseases in the world and often linked to both type 2 diabetes and obesity (Wu, Stokes Peebles)
Tolessa T, Gutniak M, Holst JJ, Efendic S, Hellstrm PM