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Enhanced expression of miR-21 resulted in a significant decrease in HMGCR mRNA and protein expression in HepG2 cells, leading to a reduction in TG and cholesterol levels [309]

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A patient with kidney disease should not take a medication like a non-steroidal anti-inflammatory, something like ibuprofen or aspirin, because that can cause kidney injury or electrolyte abnormalities

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Examples exist of brothers, harboring the same mutation, with one afflicted by the aggressive childhood form while the other suffering from a slowly progressive adrenomyeloneuropathy (Palakuzhiyil et al., 2020)