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The consistency of hepatoprotective findings across disparate injury models strengthens the biological plausibility, but a critical limitation persists: all data come from rodent studies

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Certain circulating metabolites may increase the risk of cardiovascular events and subsequent pathological responses due to changes in the microbiota (27, 28)

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In cancer cells, increased ROS will oxidize the specific isoform of pyruvate kinase (PKM2), diverting glucose flux towards the PPP and generation of NADPH for GSH recycling