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It is shorter acting and more relevant to research models focused on transient GHRH receptor activation

For instance, orlistat, which works by preventing the absorption of dietary fat, may cause gastrointestinal issues like oily stools, flatulence and abdominal cramps

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Before breakdown, however, GLP-1 in intestinal tissues has the opportunity to bind to GLP-1 receptors on the vagal afferent neurons (VAN) projecting into both the lumen and the lamina propria of the intestine