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He was inspired to do this based on the work of two Austrian scientists Ernest Pick and Friedrich Obermeyer

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Given that the liver is the primary site for the metabolism and clearance of most xenobiotics, assessing potential hepatotoxicity is essential for determining the feasibility and risk profile of any candidate compound destined for drug development (Almazroo et al., 2017

PMID 21408623

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Subgroup analysis indicated that homozygous mutations were associated with more severe impairment of long-term weight loss than heterozygous mutations, which explains why bi-allelic MC4R mutation carriers have poorer long-term outcomes than heterozygous carriers