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Methylene Blue Mechanism of Action: Methylene Blue acts on the mitochondria to enhance cellular energy production (ATP), improve cognitive function, and protect the brain from oxidative stress

Comment: One commenter requested CMS reconsider in future rulemaking requiring hospitals to encode a maximum allowed amount that would reflect the maximum total allowed amount a hospital has historically received for a third party payer for an item and service

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However, administering Vitamin B12 injections requires care and precision to ensure safety and effectiveness

Consent for publication We obtained written informed consent from all participants to publish their innominate data

Decreases in NAD+ levels have been associated with reduced neuronal signaling and impaired neuromuscular communication in animal models