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Physical manoeuvres can also interrupt the reflex: Valsalva manoeuvre : Exhale against a closed airway by pinching your nose and closing your mouth while attempting to breathe out gently for 10-15 seconds

doi: 10.1016/j.cell.2017.03.035 105 GuYAlbuquerqueCPBraasDZhangWVillaGRBiJet al

105 These results were supported by Srinivasan et al., 106 showing in their study an improvement in weight and insulin sensitivity, where using GLP-1RAs in monotherapy versus metformin achieved more than 5% weight loss

Br J Dermatol 172(5):14541455

(2017) 50:OA3416