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Animal studies have demonstrated that FOXO4-DRI can reverse many signs of aging, including: Improved muscle function and endurance Reduced kidney fibrosis and improved renal function Enhanced fur density and skin elasticity in aging mice Increased lifespan and overall resilience Additionally, FOXO4-DRI has shown promise in preventing neurodegeneration

Immune decline: Reduced efficiency in pathogen clearance and macrophage removal

The relation between glutamine and the immunodepression observed in exercise

doi:10.3390/ijms19071987 12

doi: 10.1210/jcem.83.5.4826