With continued support from the scientific community, we may soon witness the emergence of advanced therapies that harness Epithalon, ultimately giving us greater control over how we age
In cell and animal studies, glucocorticoids reduce the gene expression that produces GLP-1 in intestinal L-cells, which is a clear and well-mapped mechanism
Glia 2001
There is also a hormonal argument
(PubMed) Singh DK, Porter TD
Moreover, existing studies mostly focus on the regulation of RA synovial cells (such as FLS) or macrophages by the cGAS-STING pathway, whereas this study, for the first time, clearly demonstrates the central role of the cGAS-STING-ferroptosis axis in RA chondrocytes, and reveals that GLP-1RAs exerted therapeutic effects on RA through a dual mechanism of directly inhibiting this axis and simultaneously promoting the M2 polarization of macrophages