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The way Jardiance works to reduce the risk of cardiovascular or heart failure is thought to be related to changes in heart muscle metabolism from favoring the use of glucose to using a more balanced combination of fatty acids, ketone bodies (ketone), branched-chain amino acids (BCAA) and glucose
As more GLP-1 prescriptions are written to manage not just diabetes and cardiovascular disease but also obesity, a key question emerges: What is the role of patient engagement and chronic disease management when prescribing these drugs
Though often covered by insurance, newer GLP-1 medications are often much more expensive than other glucose-lowering medications like sulfonylureas, metformin, and thiazolidinediones
doi:10.1016/j.crad.2010.10.014 2
Studies indicate that fewer than 10 percent of eligible patients with type 2 diabetes are prescribed a GLP-1 drug