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Consistently, loss of WT1 activity in Wilms' tumour and related malignancies may result in transcriptional derepression of the IGF-1R gene (Gerald et al, 1995)

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The primary hypothalamic target for ghrelin are neurons in ARC that express and release NPY and AgRP in the lateral hypothalamus and LHA to mediate orexigenic effect in the brain (16, 17)

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