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It is produced exclusively by mature adipocytes 53 and levels are decreased in obesity, particularly visceral obesity

Yamada Y, Katagiri H, Hamamoto Y, Deenadayalan S, Navarria A, Nishijima K, Seino Y, PIONEER 9 investigators

Alcohol addiction similarly dysregulates these dopamine pathways, creating a plausible mechanistic overlap

But, some people face dangers or bad reactions when they take it

PS: I would love to hear your thoughts on whether data from medical toxicology and poison centers could be beneficial in generating hypotheses for target identification in drug discovery

At worst, you get flesh-eating bacteria and sepsis