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Adequate thyroid hormone replacement should normalize TSH levels, typically targeting the laboratory reference range for most nonpregnant adults

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The most common side effects reported were nausea and diarrhea: About half of adults who use GLP-1 agonists reported having experienced nausea, and about one-third of adults who use GLP-1 agonists reported having experienced diarrhea

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However, large-scale human trials remain limited and results vary

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